The G41D mutation in the superoxide dismutase 1 gene is associated with slow motor neuron progression and mild cognitive impairment in a Chinese family with amyotrophic lateral sclerosis.

The article discusses the case of a Chinese family with amyotrophic lateral sclerosis (ALS) associated with G41D mutation in the superoxide dismutase 1 (SOD1) gene. Topics discussed include the slow progression of the loss of motor neuron function, the occurrence of mild cognitive impairment during the later stage of ALS, and magnetic resonance imaging (MRI) which revealed significant changes in the temporal and frontal regions of the brain.