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Heart transplantation in Fontan patients across Australia and New Zealand.
Heart transplantation in Fontan patients across Australia and New Zealand.
- Source :
- Heart; 7/15/2016, Vol. 102 Issue 14, p1120-1126, 7p, 1 Diagram, 3 Charts, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>Patients with Fontan physiology may eventually require heart transplantation (HT). We determined the rates and outcomes of HT in a national, population-based multicentre study.<bold>Methods: </bold>From 1990 to 2015, 1369 patients underwent the Fontan procedure as recorded in the Australia and New Zealand Fontan Registry. We identified those who underwent HT and analysed their outcomes. We compared rates of HT between two catchment areas. In area 1 (n=721), patients were referred to the national paediatric HT programme or its associated adult programme. In area 2 (n=648), patients were referred to the national paediatric HT programme or one of the other adult HT programmes.<bold>Results: </bold>Mean follow-up time post-Fontan was 11±8 years. Freedom from Fontan failure was 74%±3.9% at 20 years. HT was performed in 34 patients. Patients living in area 1 were more likely to have HT (4.0%, 29/721 vs 0.8%, 5/648, p<0.001) with a cumulative proportion of 3.4% vs 0.7% at 10 years and 6.8% vs 1.2% at 20 years (p=0.002). Area 1 patients were more likely to undergo HT (hazard ratio 4.7, 95% CI 1.7 to 13.5, p=0.003) on multivariable regression. Post-HT survival at 1, 5 and 10 years was 91%, 78% and 71%, respectively. Compared with other patients with congenital heart disease (n=87), Fontan patients had similar in-hospital outcomes and long-term survival.<bold>Conclusions: </bold>Although HT after the Fontan procedure can be achieved with excellent outcomes, most patients with Fontan failure do not undergo HT. Significant regional differences in rates of HT in Fontan patients exist. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART transplantation
CARDIAC surgery
PEDIATRIC surgery
HEALTH outcome assessment
REGRESSION analysis
CONGENITAL heart disease diagnosis
CARDIOPULMONARY bypass
CHAOS theory
CHI-squared test
COMPARATIVE studies
CONGENITAL heart disease
HEALTH service areas
HEALTH services accessibility
HEALTH status indicators
RESEARCH methodology
MEDICAL cooperation
MEDICAL referrals
MULTIVARIATE analysis
PROGNOSIS
RESEARCH
SURGICAL complications
TIME
EVALUATION research
TREATMENT effectiveness
ACQUISITION of data
PROPORTIONAL hazards models
RETROSPECTIVE studies
KAPLAN-Meier estimator
SURGERY
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 13556037
- Volume :
- 102
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Heart
- Publication Type :
- Academic Journal
- Accession number :
- 116409962
- Full Text :
- https://doi.org/10.1136/heartjnl-2015-308848