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Palladium-Catalyzed Regioselective C-H Acetoxylation of 2-Aryloxypyridines with 2-Pyridyloxy as a Removable Directing Group.
- Source :
- European Journal of Organic Chemistry; Jun2016, Vol. 2016 Issue 18, p3113-3118, 6p
- Publication Year :
- 2016
-
Abstract
- A simple and regioselective palladium-catalyzed ortho-C(sp<superscript>2</superscript>)-H acetoxylation of 2-aryloxypyridines with PhI(OAc)<subscript>2</subscript> as both the oxidant and acetate source has been developed. The mono- and di-acetoxylated products can be achieved by tuning the equivalents of PhI(OAc)<subscript>2</subscript> and the reaction temperature. A wide range of 2-aryloxypyridines is tolerated. Moreover, 2-pyridyloxyl and acetyl groups can be easily removed, which provides straightforward access to poly-substituted phenols. [ABSTRACT FROM AUTHOR]
- Subjects :
- PALLADIUM
PYRIDINE
OXIDIZING agents
ACETATES
PHENOLS
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 116465765
- Full Text :
- https://doi.org/10.1002/ejoc.201600508