Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla.

Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A ( 1) and B ( 2), together with seven known compounds. Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry, as well as chemical methods. In addition, the cytotoxicity of the two new saponins was tested. Graphical Abstract: Two new highly oxygenated spirostanol saponins, paristenosides A ( 1) and B ( 2), were isolated from the rhizomes of Paris polyphylla var. stenophylla. Their structures were established mainly based on NMR spectroscopic techniques and mass spectrometry, as well as chemical methods.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]