Back to Search
Start Over
Early predictors of a clinical response at 8 weeks in patients with first-episode psychosis treated with paliperidone ER.
- Source :
- Journal of Psychopharmacology; Aug2016, Vol. 30 Issue 8, p810-818, 9p
- Publication Year :
- 2016
-
Abstract
- Identification of early clinical markers that predict later treatment outcomes in first-episode psychosis is highly valuable. The present study was conducted to determine the best time at which to predict the late treatment response in first-episode psychosis patients treated with paliperidone extended release (ER), the factors predicting early treatment responses (at Week 2 and Week 3) and the relationships between the paliperidone ER plasma concentrations at Week 2 and Week 3, and the treatment responses at Week 2, Week 3 and Week 8. Various criteria for assessing treatment response were employed. We determined the plasma paliperidone concentrations at Week 2 and Week 3, using validated high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). The treatment response at Week 3 optimally predicted the later (Week 8) response, in terms of negative predictive value (NPV). Independent predictors for good treatment responses at Week 2 and Week 3 were: Female gender, a higher educational level, a higher Positive and Negative Syndrome Scale (PANSS) excited score, and/or a shorter duration of untreated psychosis (DUP). The plasma paliperidone concentration at Week 3, but not Week 2, was a significant predictor of the late treatment response at Week 8. These results may help appropriate clinical decision-making for early non-responders after having their first episode of psychosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSYCHOSES
ENDOPLASMIC reticulum
PLASMA gases
DECISION making
LIQUID chromatography
DRUG therapy for psychoses
ANTIPSYCHOTIC agents
CLINICAL trials
COMPARATIVE studies
CONTROLLED release preparations
HIGH performance liquid chromatography
MASS spectrometry
RESEARCH methodology
MEDICAL cooperation
PSYCHOLOGICAL tests
RESEARCH
SEX distribution
EVALUATION research
TREATMENT effectiveness
Subjects
Details
- Language :
- English
- ISSN :
- 02698811
- Volume :
- 30
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 116808420
- Full Text :
- https://doi.org/10.1177/0269881116654698