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AgI-Promoted Cascade for Difluoromethylation of Activated Alkenes to Difluoromethylated Oxindoles.
- Source :
- European Journal of Organic Chemistry; Aug2016, Vol. 2016 Issue 22, p3773-3779, 7p
- Publication Year :
- 2016
-
Abstract
- A simple Ag<superscript>I</superscript>-mediated direct difluoromethylation reaction of activated alkenes by using TMSCF<subscript>2</subscript>COOEt (TMS = trimethylsilyl) under mild reaction conditions has been described. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various difluoro-containing oxindoles. Mechanistic investigations indicate that a difluoromethyl radical initiated the cascade sequence by undergoing an addition reaction to the alkene. [ABSTRACT FROM AUTHOR]
- Subjects :
- NITROGEN
HETEROCYCLIC compounds
FLUORINE
RADICALS (Chemistry)
SILVER
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 117296899
- Full Text :
- https://doi.org/10.1002/ejoc.201600461