Back to Search
Start Over
Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems.
- Source :
- Journal of Materials Chemistry B; 8/28/2016, Vol. 4 Issue 32, p5446-5454, 9p
- Publication Year :
- 2016
-
Abstract
- DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core–shell structure but were instead based on the copolymers of N-isopropylacrylamide and acrylamide and DNA crosslinks. By incorporating the aptamer-functionalized moieties, the AptMG–Dox system was demonstrated to possess excellent biocompatibility and highly selective killing efficacy for target cancer cells via stimuli-responsiveness, which could provide immense potential as an intelligent drug delivery carrier for targeted cancer therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 4
- Issue :
- 32
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 117364706
- Full Text :
- https://doi.org/10.1039/c6tb01224h