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Doxorubicin nanobubble for combining ultrasonography and targeted chemotherapy of rabbit with VX2 liver tumor.
- Source :
- Tumor Biology (Springer Science & Business Media B.V.); Jul2016, Vol. 37 Issue 7, p8673-8680, 8p
- Publication Year :
- 2016
-
Abstract
- A new class of multifunctional nanobubble using poly(lactic-co-glycolic acid) (PLGA) has been developed as ultrasound imaging contrast agents, doxorubicin carriers, and enhancers of ultrasound-mediated drug delivery. The doxorubicin nanobubble (DOX-NB) wrapping carbon tetrafluoride gas was prepared with double emulsion method. We evaluated the enhanced ultrasonic function of the DOX-NB in vivo; its antitumor function was confirmed. The diameter of the prepared bubble was 500 nm, and the potential was −23 mV. The drug loading and encapsulation efficiency of the bubble were 78.6 and 7.4 %, respectively. Therefore, the DOX-NB greatly enhanced ultrasound imaging in vivo. Ultrasound combined with DOX-NB had significant antitumor effect. Compared with other groups, the tumor growth rate and the proliferation index were the lowest while the survival rate and apoptosis index were the highest. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10104283
- Volume :
- 37
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Tumor Biology (Springer Science & Business Media B.V.)
- Publication Type :
- Academic Journal
- Accession number :
- 117522467
- Full Text :
- https://doi.org/10.1007/s13277-015-4525-5