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Second-Line Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian, Tubal and Peritoneal Cancer: A Propensity Score-Matching Study.
- Source :
- Chemotherapy (0009-3157); Aug2016, Vol. 61 Issue 5, p240-248, 9p
- Publication Year :
- 2016
-
Abstract
- Background: The superiority of frontline intraperitoneal (IP) over intravenous (IV) chemotherapy is well established in the treatment of epithelial ovarian cancer. However, the role of IP chemotherapy in the second-line setting has rarely been investigated. Methods: Consecutive patients diagnosed with recurrent epithelial, tubal and peritoneal cancers between January 2000 and December 2012 were recruited using a propensity score-matching technique to adjust relevant risk factors. Results: In total, 310 patients were included in the final analysis (94 for platinum-refractory/resistant disease and 216 for platinum-sensitive disease). IP chemotherapy demonstrated significantly longer median progressionfree survival than IV chemotherapy (4.9 vs. 2.4 months, p < 0.001, for platinum-refractory/resistant disease, and 9.8 vs. 6.9 months, p < 0.001, for platinum-sensitive disease). Conclusions: Second-line IP chemotherapy confers longer progression- free survival than IV chemotherapy. Large-scale clinical trials should be conducted to validate the true efficacy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093157
- Volume :
- 61
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Chemotherapy (0009-3157)
- Publication Type :
- Academic Journal
- Accession number :
- 117697650
- Full Text :
- https://doi.org/10.1159/000443924