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MWA Versus RFA for Perivascular and Peribiliary CRLM: A Retrospective Patient- and Lesion-Based Analysis of Two Historical Cohorts.
- Source :
- CardioVascular & Interventional Radiology; Oct2016, Vol. 39 Issue 10, p1438-1446, 9p
- Publication Year :
- 2016
-
Abstract
- <bold>Purpose: </bold>To retrospectively analyse the safety and efficacy of radiofrequency ablation (RFA) versus microwave ablation (MWA) in the treatment of unresectable colorectal liver metastases (CRLM) in proximity to large vessels and/or major bile ducts.<bold>Method and Materials: </bold>A database search was performed to include patients with unresectable histologically proven and/or (18)F-FDG-PET avid CRLM who were treated with RFA or MWA between January 2001 and September 2014 in a single centre. All lesions that were considered to have a peribiliary and/or perivascular location were included. Univariate logistic regression analysis was performed to assess the distribution of patient, tumour and procedure characteristics. Multivariate logistic regression was used to correct for potential confounders.<bold>Results: </bold>Two hundred and forty-three patients with 774 unresectable CRLM were ablated. One hundred and twenty-two patients (78 males; 44 females) had at least one perivascular or peribiliary lesion (n = 199). Primary efficacy rate of RFA was superior to MWA after 3 and 12 months of follow-up (P = 0.010 and P = 0.022); however, after multivariate analysis this difference was non-significant at 12 months (P = 0.078) and vanished after repeat ablations (P = 0.39). More CTCAE grade III complications occurred after MWA versus RFA (18.8 vs. 7.9 %; P = 0.094); biliary complications were especially common after peribiliary MWA (P = 0.002).<bold>Conclusion: </bold>For perivascular CRLM, RFA and MWA are both safe treatment options that appear equally effective. For peribiliary CRLM, MWA has a higher complication rate than RFA, with similar efficacy. Based on these results, it is advised to use RFA for lesions in the proximity of major bile ducts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01741551
- Volume :
- 39
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- CardioVascular & Interventional Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 117808968
- Full Text :
- https://doi.org/10.1007/s00270-016-1413-3