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Antioxidant and anti-adipogenic activities of chestnut ( Castanea crenata) byproducts.
- Source :
- Food Science & Biotechnology; Aug2016, Vol. 25 Issue 4, p1169-1174, 6p
- Publication Year :
- 2016
-
Abstract
- The antioxidant and anti-adipogenic activities of chestnut byproducts were evaluated. At 100 μg/mL, the methanol extract (ME) scavenged 34.2% of DPPH and 78.8% of ABTS radicals. The DPPH and ABTS radical scavenging activity of the water extract (WE) was found to be low (13.7 and 33.1%, respectively) compared with controls. WE and ME dose-dependently inhibited lipid accumulation of 3T3-L1 adipocytes. WE and ME at 100 μg/mL suppressed 3T3-L1 adipogenesis by 71.0 and 96.5%, respectively, when compared with mature adipocytes. The results indicated that WE and ME inhibited adipocyte differentiation by down-regulating the mRNA expression levels of CCAAT/enhancer binding protein (C/EBP)-β, C/EBPα, and peroxisome proliferator-activated receptor (PPAR)-γ in 3T3-L1 cells. Our study also revealed that WE and ME inhibited pre- and early stage adipogenesis in 3T3-L1 cells. The results suggest that chestnut byproducts are a promising source of antioxidant and antiobesity molecules. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12267708
- Volume :
- 25
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Food Science & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 117922374
- Full Text :
- https://doi.org/10.1007/s10068-016-0186-4