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Selective expansion of regulatory T cells during lenalidomide treatment of myelodysplastic syndrome with isolated deletion 5q.
- Source :
- Annals of Hematology; Oct2016, Vol. 95 Issue 11, p1805-1810, 6p
- Publication Year :
- 2016
-
Abstract
- Lenalidomide (LEN) leads to erythroid improvement in the majority of patients with myelodysplastic syndrome and isolated deletion of the long arm of chromosome 5 (MDS-del(5q)). This effect is believed to be exerted via its immunomodulatory properties, although the precise nature is still incompletely understood. We prospectively performed immune profiling in the bone marrow and blood of MDS-del(5q) patients undergoing LEN therapy for a median of 6 cycles. Therapy with LEN led to a significant increase in the median absolute lymphocyte count (1.3-fold, p = 0.013) without changes in the distribution of the T helper cells within the entire compartment. In parallel, the frequency of Treg increased significantly during treatment both in the peripheral blood (5.0 vs. 9.6 %, p = 0.001) and bone marrow (3.4 vs. 8.1 %, p = 0.001). Surprisingly, LEN treatment led to a decrease in TGFbeta levels, both in the peripheral blood (4.9 vs. 2.3 ng/ml, p = 0.039) and bone marrow (4.5 vs. 0.8 ng/ml, p = 0.023). These changes were not associated with an increase in pro-inflammatory Th17 cells. Taken together, our results demonstrate that LEN induces a shift in lymphocytic populations towards immunosuppression in MDS-del(5q) patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- T helper cells
T cells
HEMATOLOGIC agents
MYELODYSPLASTIC syndromes treatment
MYELODYSPLASTIC syndromes
CHROMOSOME abnormalities
LYMPHOCYTE count
THERAPEUTICS
BONE marrow
CHROMOSOMES
CLINICAL trials
COMPARATIVE studies
GROWTH factors
IMMUNOLOGICAL adjuvants
RESEARCH methodology
MEDICAL cooperation
GENETIC mutation
RESEARCH
EVALUATION research
THALIDOMIDE
MACROCYTIC anemia
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 09395555
- Volume :
- 95
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Annals of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 118413896
- Full Text :
- https://doi.org/10.1007/s00277-016-2775-y