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Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy.
- Source :
- Annals of Medicine; Sep2016, Vol. 48 Issue 6, p417-427, 11p
- Publication Year :
- 2016
-
Abstract
- Objective:We assessed the value of speckle tracking two-dimensional (2D) strain echocardiography (2DSE) measured mechanical dispersion (MD) with other imaging and electrocardiographic parameters in differentiating hypertrophic cardiomyopathy (HCM) patients with and without nonsustained ventricular tachycardia (NSVT) on 24-h ambulatory ECG monitoring. Methods and results:We studied 31 patients with HCM caused by the Finnish founder mutationMYBPC3-Q1061X and 20 control subjects with comprehensive 2DSE echocardiography and cardiac magnetic resonance imaging (CMRI). The presence of NSVT was assessed from ambulatory 24-h ECG monitoring. NSVT episodes were recorded in 11 (35%) patients with HCM. MD was significantly higher in HCM patients with NSVT (93 ± 41 ms) compared to HCM patients without NSVT (50 ± 18 ms, p = 0.012) and control subjects (41 ± 16 ms, p < 0.001). MD was the only variable independently associated with the presence of NSVT (OR: 1.60, 95% CI: 1.05–2.45, p = 0.030). Assessed by ROC curves, MD performed best in differentiating between HCM patients with and without NSVT (AUC = 0.81). Conclusions:Increased mechanical dispersion was associated with NSVT in HCM patients on 24-h ambulatory ECG monitoring.Key messagesThe prediction of sudden cardiac death in hypertrophic cardiomyopathy remains a challenge and novel imaging methods are required to identify individuals at risk of malignant ventricular arrhythmias.Mechanical dispersion by speckle tracking echocardiography is associated with NSVT on 24-h ambulatory ECG monitoring in patients with hypertrophic cardiomyopathy [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 07853890
- Volume :
- 48
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Annals of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 118479800
- Full Text :
- https://doi.org/10.1080/07853890.2016.1186826