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The emerging role of non-coding circulating RNA as a biomarker in renal cell carcinoma.
- Source :
- Expert Review of Molecular Diagnostics; Oct2016, Vol. 16 Issue 10, p1059-1065, 7p
- Publication Year :
- 2016
-
Abstract
- Introduction:Bodily fluids like serum and plasma contain significant amounts of tumor-derived circulating cell-free RNA, which holds the potential to serve as diagnostic biomarker. Consequently, liquid biopsies comprising circulating cell-free RNA might help to facilitate personalized treatment strategies for patients with renal cell carcinoma (RCC). Areas covered:The present review provides a summary of the literature obtained by a PubMed search and covers the current knowledge on circulating non-coding cell-free RNA in patients with RCC. Expert commentary:Altered circulating microRNA and long non-coding RNAs signatures allow for the discrimination of patients with RCC and healthy individuals. On the other hand, little is known about non-coding RNA expression in benign tumors. Cell-free microRNA expression levels may help to identify patients at risk for disease recurrence. However, accurate determination of cell-free RNAs is methodologically challenging and currently no biomarker candidate has reached a sufficient level of clinical validation. Thus, short-term implementation of cell-free circulating microRNA into clinical routine seems unlikely. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 14737159
- Volume :
- 16
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Expert Review of Molecular Diagnostics
- Publication Type :
- Academic Journal
- Accession number :
- 118509974
- Full Text :
- https://doi.org/10.1080/14737159.2016.1239531