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Impact of Improved Left Ventricular Systolic Function on the Recurrence of Ventricular Arrhythmia in Heart Failure Patients With an Implantable Cardioverter-Defibrillator.
- Source :
- Journal of Cardiovascular Electrophysiology; Oct2016, Vol. 27 Issue 10, p1191-1198, 8p, 1 Diagram, 4 Charts, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- Improvement of Ejection Fraction and ICD Therapy Introduction Data are lacking on the relationship between improved left ventricular ejection fraction (LVEF) and the incidence of ventricular arrhythmia in patients with an implantable cardioverter-defibrillator (ICD) for secondary prevention. The aim of this study was to evaluate the incidence and predictors of improvement in left ventricular (LV) function and determine the impact of improved LVEF on the occurrence of appropriate ICD therapy in patients with reduced LVEF and ICD for secondary prevention. Methods In this study, 93 patients who received ICDs for secondary prevention, had an LVEF of < 45%, and underwent echocardiographic follow-up assessment after receiving an ICD were enrolled. Results The mean patient age was 56.9 ± 13.1 years, the median time of repeat LVEF assessment was 19.7 (10.4-29.7) months, and the mean LVEF was 30.6 ± 8.5%. Of the patients, 58 (62.4%) had nonischemic cardiomyopathy. LV function improved after ICD implantation in 24 (25.8%) of 93 patients. Multivariable logistic regression revealed a short duration from the time of diagnosis of heart failure to ICD implantation and the presence of ventricular fibrillation as significant predictors of improved LV function. The incidence of appropriate ICD therapy was lower in the patients with than in those without LV function improvement. The composite endpoint of all-cause mortality or heart transplant was lower in the patients with than in those without LV function improvement. Conclusion Overall survival was better and the recurrence of ventricular arrhythmia was lower in the patients with improved LV function. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACADEMIC medical centers
CONFIDENCE intervals
ELECTROCARDIOGRAPHY
LEFT heart ventricle
HEART physiology
IMPLANTABLE cardioverter-defibrillators
PROBABILITY theory
T-test (Statistics)
DISEASE relapse
MULTIPLE regression analysis
RETROSPECTIVE studies
RECEIVER operating characteristic curves
DATA analysis software
DESCRIPTIVE statistics
KAPLAN-Meier estimator
VENTRICULAR arrhythmia
LOG-rank test
ODDS ratio
MANN Whitney U Test
VENTRICULAR ejection fraction
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10453873
- Volume :
- 27
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 118833281
- Full Text :
- https://doi.org/10.1111/jce.13037