T REG Cells in Cancer: Beyond Classical Immunological Control.

A prerequisite for tumor evolution toward a malignant state is the establishment of cell intrinsic and extrinsic mechanisms of immune suppression (Hanahan and Weinberg, 2000, 2011; Schreiber, Old, and Smyth, 2011). Widespread recruitment of Foxp3+regulatory T cells (TREG) is a prevailing means to dampen antitumor immunity. Advances in the characterization of TREGcell heterogeneity and physiological function of tissue resident TREGcells unfold new possibilities for nontraditional tumor-promoting functions of intratumoral TREGcells. This review will focus on the nonclassical function of TREGcells and their implicancies for cancer biology and treatment. [ABSTRACT FROM AUTHOR]