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T REG Cells in Cancer: Beyond Classical Immunological Control.
- Source :
- Immunological Investigations; Nov2016, Vol. 45 Issue 8, p721-728, 8p
- Publication Year :
- 2016
-
Abstract
- A prerequisite for tumor evolution toward a malignant state is the establishment of cell intrinsic and extrinsic mechanisms of immune suppression (Hanahan and Weinberg, 2000, 2011; Schreiber, Old, and Smyth, 2011). Widespread recruitment of Foxp3+regulatory T cells (TREG) is a prevailing means to dampen antitumor immunity. Advances in the characterization of TREGcell heterogeneity and physiological function of tissue resident TREGcells unfold new possibilities for nontraditional tumor-promoting functions of intratumoral TREGcells. This review will focus on the nonclassical function of TREGcells and their implicancies for cancer biology and treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08820139
- Volume :
- 45
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Immunological Investigations
- Publication Type :
- Academic Journal
- Accession number :
- 119027273
- Full Text :
- https://doi.org/10.1080/08820139.2016.1222206