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Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?
- Source :
- PLoS ONE; 11/8/2016, Vol. 11 Issue 11, p1-19, 19p
- Publication Year :
- 2016
-
Abstract
- Crohn’s Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1<superscript>High</superscript>/Th2<superscript>Low</superscript> while, by contrast, the group with Th1<superscript>Low</superscript>/Th2<superscript>High</superscript> will benefit from immune activation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 119321270
- Full Text :
- https://doi.org/10.1371/journal.pone.0165782