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LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma.
- Source :
- OncoImmunology; 2016, Vol. 5 Issue 11, pN.PAG-N.PAG, 1p
- Publication Year :
- 2016
-
Abstract
- Immunotherapy with immune checkpoint molecule-specific monoclonal antibody have obtained encouraging results from preclinical studies and clinical trials, which promoted us to explore whether this kind of immunotherapy could be applicable to head and neck squamous cell carcinoma (HNSCC). Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint control protein that negatively regulates T cells and immune response. Here, using the human tissue samples, we report these findings that LAG-3 is overexpressed on tumor-infiltrating lymphocytes (TILs;p< 0.001) and its overexpression correlates with the high pathological grades, lager tumor size and positive lymph node status in human primary HNSCC. Survival analysis identifies LAG-3 as a prognostic factor independent of tumor size and pathological grades for primary HNSCC patients with negative lymph node status (p= 0.014). Study in immunocompetent genetically defined HNSCC mouse model reports that LAG-3 is upregulated on CD4+T cells, CD8+T cells and CD4+Foxp3+regulatory T cells (Tregs).In vivostudy, administration of LAG-3-specific antibody retards tumor growth in a way associated with enhanced systemic antitumor response by potentiating the antitumor response of CD8+T cells and decreasing the population of immunosuppressive cells. Taken together, our results offer a preclinical proof supporting the immunomodulatory effects of LAG-3 and suggest a potential therapeutic target of immunotherapy for HNSCC. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEAD & neck cancer
INTERLEUKIN-1
CANCER immunotherapy
GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 5
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 119784472
- Full Text :
- https://doi.org/10.1080/2162402X.2016.1239005