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Low Double-Negative CD3+CD4-CD8- T Cells Are Associated with Incomplete Restoration of CD4+ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders.
- Source :
- Frontiers in Immunology; 12/9/2016, Vol. 7, p1-8, 8p
- Publication Year :
- 2016
-
Abstract
- Failure of immune reconstitution increases the risk of AIDS or non-AIDS related morbidity and mortality in HIV-1-infected patients. CD3+CD4<superscript>-</superscript>CD8<superscript>-</superscript> T cells, which are usually described as double-negative (DN) T cells, display CD4-like helper and immunoregulatory functions. Here, we have measured the percentage of DN T cells in the immune reconstituted vs. non-immune reconstituted HIV-1-infected individuals. We observed that immunological non-responders (INRs) had a low number of DN T cells after long-term antiretroviral therapy (ART), and the number of these cells positively correlated with the CD4<superscript>+</superscript> T cell count. The ART did not result in complete suppression of immune activation recorded by the percentage of CD38<superscript>+</superscript>HLA-DR<superscript>+</superscript>CD8<superscript>+</superscript> T cells in INRs, and a strong inverse correlation was observed between DN T cells and immune activation. A low proportion of TGF-β1<superscript>+</superscript>DN T cells was found in INRs. Further mechanism study demonstrated that the level of TGF-β1-producing DN T cells and immune activation had a negative correlation after ART. Taken together, our study suggests that DN T cells control the immunological response in HIV-1-infected patients. These findings expand our understanding of the mechanism of immune reconstitution and could develop specific treatments to return the immune system to homeostasis following initiation of HIV-1 therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections -- Immunological aspects
T cells
CD antigens
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 7
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 120163464
- Full Text :
- https://doi.org/10.3389/fimmu.2016.00579