Hydrothermal Synthesis of Monodispersed BaGdF5:Yb/Er Nanoparticles for CT and MR Imaging.

In this paper, we report the development of a facile one-pot hydrothermal method for the controlled synthesis of monodispersed BaGdF₅ :Yb/Er nanoparticles for computed tomography ( CT) and magnetic resonance ( MR) imaging. The as-prepared nanoparticles have uniform size with a diameter of 20-25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/ mL, suggesting that the as-prepared BaGdF₅ :Yb/Er nanoparticles possess low toxicity. For both BaGdF₅ :Yb/Er nanoparticles and iopromide, the Hounsfield unit ( HU) values increase with the their concentration. The slope of BaGdF₅ :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF₅ :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF₅ :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging. [ABSTRACT FROM AUTHOR]