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Second malignancies in hydroxyurea and interferon-treated Philadelphia-negative myeloproliferative neoplasms.

Authors :
Hansen, Iben Onsberg
Sørensen, Anders Lindholm
Hasselbalch, Hans Carl
Source :
European Journal of Haematology; Jan2017, Vol. 98 Issue 1, p75-84, 10p
Publication Year :
2017

Abstract

Objective In an era of controversy in regard to 'hydroxyurea-leukaemogenicity' and when interferon-alfa2 ( IFN) is being revived in the treatment of Philadelphia-negative myeloproliferative neoplasms ( MPNs), we aim in this single-centre observational study to describe the frequencies of second malignancies in a cohort of MPN patients treated with hydroxyurea ( HU) or IFN monotherapy or the combination of these agents. Patients and methods Records of a MPN cohort of 196 patients were reviewed, and a retrospective analysis was performed on 90 patients treated with HU, 38 patients treated with IFN and 68 patients treated with both IFN and HU. Logistic regression was used to compare frequencies in second malignancies. Results Patients treated with HU had a significantly higher risk of developing all second malignancies compared with patients treated with IFN [ HU vs. IFN: OR of 4.01 (95% CI: 1.12-14.27, P-value: 0.023) and HU- IFN vs. IFN: OR 5.58 (95% CI: 1.55-20.15, P-value: 0.004)]. Conclusion We have found an increased risk of second malignancies in MPN patients treated with HU compared with patients treated with IFN. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09024441
Volume :
98
Issue :
1
Database :
Complementary Index
Journal :
European Journal of Haematology
Publication Type :
Academic Journal
Accession number :
120281707
Full Text :
https://doi.org/10.1111/ejh.12787