Two new estimators for the proportion of true null hypotheses in multiple test.

In multiple hypothesis test, an important problem is estimating the proportion of true null hypotheses. Existing methods are mainly based on thep-values of the single tests. In this paper, we propose two new estimations for this proportion. One is a natural extension of the commonly used methods based onp-values and the other is based on a mixed distribution. Simulations show that the first method is comparable with existing methods and performs better under some cases. And the method based on a mixed distribution can get accurate estimators even if the variance of data is large or the difference between the null hypothesis and alternative hypothesis is very small. [ABSTRACT FROM PUBLISHER]