Transition state isosteres of the γ-glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH2NH] pseudopeptide analogue of glutathione.

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ-Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]