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Litchi seed extract inhibits epidermal growth factor receptor signaling and growth of Two Non-small cell lung carcinoma cells.
- Source :
- BMC Complementary & Alternative Medicine; 1/5/2017, Vol. 17, p1-9, 9p, 1 Diagram, 3 Graphs
- Publication Year :
- 2017
-
Abstract
- Background: Litchi seeds possess rich amounts of phenolics and have been shown to inhibit proliferation of several types of cancer cells. However, the suppression of EGFR signaling in non-small cell lung cancer (NSCLC) by litchi seed extract (LCSE) has not been fully understood. Methods: In this study, the effects of LCSE on EGFR signaling, cell proliferation, the cell cycle and apoptosis in A549 adenocarcinoma cells and NCI- H661 large-cell carcinoma cells were examined. Results: The results demonstrated that LCSE potently reduced the number of cancer cells and induced growth inhibition, cell-cycle arrest in the G1 or G2/M phase, and apoptotic death in the cellular experiment. Only low cytotoxicity effect was noted in normal lung MRC-5 cells. LCSE also suppressed cyclins and Bcl-2 and elevated Kip1/p27, Bax and caspase 8, 9 and 3 activities, which are closely associated with the downregulation of EGFR and its downstream Akt and Erk-1/-2 signaling. Conclusion: The results implied that LCSE suppressed EGFR signaling and inhibited NSCLC cell growth. This study provided in vitro evidence that LCSE could serve as a potential agent for the adjuvant treatment of NSCLC. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNG cancer prevention
SEEDS
THERAPEUTIC use of plant extracts
CHINESE medicine
APOPTOSIS
BIOLOGICAL transport
CELL cycle
CULTURE media (Biology)
FLOW cytometry
GROWTH factors
HERBAL medicine
IMMUNOBLOTTING
REGRESSION analysis
RESEARCH funding
T-test (Statistics)
DESCRIPTIVE statistics
IN vitro studies
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 14726882
- Volume :
- 17
- Database :
- Complementary Index
- Journal :
- BMC Complementary & Alternative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 120577167
- Full Text :
- https://doi.org/10.1186/s12906-016-1541-y