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Divide, conquer, and sense: CD8+CD28- T cells in Perspective.
- Source :
- Frontiers in Immunology; 1/3/2017, Vol. 7, p1-9, 9p
- Publication Year :
- 2017
-
Abstract
- Understanding the rationale for the generation of a pool of highly differentiated effector memory CD8<superscript>+</superscript> T cells displaying a weakened capacity to scrutinize for peptides complexed with major histocompatibility class I molecules via their T cell receptor, lacking the "signal 2" CD28 receptor, and yet expressing a highly diverse array of innate receptors, from natural killer receptors, interleukin receptors, and damage-associated molecular pattern receptors, among others, is one of the most challenging issues in contemporary human immunology. The prevalence of these differentiated CD8<superscript>+</superscript> T cells, also known as CD8<superscript>+</superscript>CD28<superscript>-</superscript>, CD8<superscript>+</superscript>KIR<superscript>+</superscript>, NK-like CD8<superscript>+</superscript> T cells, or innate CD8<superscript>+</superscript> T cells, in non-lymphoid organs and tissues, in peripheral blood of healthy elderly, namely centenarians, but also in stressful and chronic inflammatory conditions suggests that they are not merely end-of-the-line dysfunctional cells. These experienced CD8<superscript>+</superscript> T cells are highly diverse and capable of sensing a variety of TCR-independent signals, which enables them to respond and fine-tune tissue homeostasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- CD8 antigen
CD28 antigen
CELLULAR signal transduction
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 7
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 120578997
- Full Text :
- https://doi.org/10.3389/fimmu.2016.00665