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Surgical treatment of childhood hepatoblastoma in the Netherlands (1990-2013).

Authors :
Busweiler, Linde
Wijnen, Marc
Wilde, Jim
Sieders, Egbert
Terwisscha van Scheltinga, Sheila
Heurn, L.
Ziros, Joseph
Bakx, Roel
Heij, Hugo.
Busweiler, Linde A D
Wijnen, Marc H W A
Wilde, Jim C H
Terwisscha van Scheltinga, Sheila E J
van Heurn, L W Ernest
Heij, Hugo A
Source :
Pediatric Surgery International; Jan2017, Vol. 33 Issue 1, p23-31, 9p, 3 Diagrams, 4 Charts, 1 Graph
Publication Year :
2017

Abstract

<bold>Background: </bold>Achievement of complete surgical resection plays a key role in the successful treatment of children with hepatoblastoma. The aim of this study is to assess the surgical outcomes after partial liver resections for hepatoblastoma, focusing on postoperative complications, resection margins, 30-day mortality, and long-term survival.<bold>Method: </bold>Chart reviews were carried out on all patients treated for hepatoblastoma in the Netherlands between 1990 and 2013.<bold>Results: </bold>A total of 103 patients were included, of whom 94 underwent surgery. Partial hepatectomy was performed in 76 patients and 18 patients received a liver transplant as a primary procedure. In 42 of 73 (58 %) patients, one or more complications were reported. In 3 patients, information regarding complications was not available. Hemorrhage necessitating blood transfusion occurred in 33 (45 %) patients and 9 (12 %) patients developed biliary complications, of whom 8 needed one or more additional surgical interventions. Overall, 5-year disease-specific survival was 82, 92 % in the group of patients who underwent partial hepatectomy, and 77 % in the group of patients who underwent liver transplantation.<bold>Conclusions: </bold>Partial hepatectomy after chemotherapy in children with hepatoblastoma offers good chances of survival. This type of major surgery is associated with a high rate of surgical complications (58 %), which is not detrimental to survival. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01790358
Volume :
33
Issue :
1
Database :
Complementary Index
Journal :
Pediatric Surgery International
Publication Type :
Academic Journal
Accession number :
120643648
Full Text :
https://doi.org/10.1007/s00383-016-3989-8