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Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice.
- Source :
- European Journal of Oral Sciences; Feb2017, Vol. 125 Issue 1, p28-33, 6p, 1 Color Photograph, 1 Diagram, 3 Graphs
- Publication Year :
- 2017
-
Abstract
- Immunosuppressive agents have been recognized as a factor affecting bone metabolism. The aim of the present study was to evaluate the influence of FK-506 administration on the healing of bone around titanium implants. Thirty-two male mice were randomly allocated to two groups: the FK-506 group ( n = 16 mice), which received subcutaneous administration of FK-506 (1 mg kg<superscript>−1</superscript> d<superscript>−1</superscript>); and the control group ( n = 16 mice), which received saline solution by the same route of administration. After 2 wk, one titanium implant with sandblasted/acid-etched surface was placed in the femur. The therapy continued until the mice were killed 2 and 4 wk after surgery. The femurs with implants were evaluated by biomechanical testing and histologic analysis. The bone-implant contact ( BIC) and bone volume ( BV/ TV) within a 100- μm-wide circumferential zone lateral to the implant surface were histomorphometrically analyzed. Compared with the control group, the FK-506 group showed significantly lower BIC and BV/ TV at both 2 and 4 wk. Biomechanical tests showed that FK-506 significantly impaired the strength of bone-implant integration at both 2 and 4 wk postoperatively. Our data indicate that immunosuppressive therapy with FK-506 negatively affects the fixation of titanium implants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09098836
- Volume :
- 125
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Oral Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 120747066
- Full Text :
- https://doi.org/10.1111/eos.12320