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LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7 /AKT /DAF-16 axis.
- Source :
- Aging Cell; Feb2017, Vol. 16 Issue 1, p113-124, 12p
- Publication Year :
- 2017
-
Abstract
- The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28 -regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14749718
- Volume :
- 16
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Aging Cell
- Publication Type :
- Academic Journal
- Accession number :
- 120748214
- Full Text :
- https://doi.org/10.1111/acel.12539