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PD-L1 expression in papillary renal cell carcinoma.

Authors :
Takanobu Motoshima
Yoshihiro Komohara
Chaoya Ma
Arni Kusuma Dewi
Hirotsugu Noguchi
Sohsuke Yamada
Toshiyuki Nakayama
Shohei Kitada
Yoshiaki Kawano
Wataru Takahashi
Masaaki Sugimoto
Motohiro Takeya
Naohiro Fujimoto
Yoshinao Oda
Masatoshi Eto
Motoshima, Takanobu
Komohara, Yoshihiro
Ma, Chaoya
Dewi, Arni Kusuma
Noguchi, Hirotsugu
Source :
BMC Urology; 1/13/2017, Vol. 17, p1-6, 6p
Publication Year :
2017

Abstract

<bold>Background: </bold>The immune escape or tolerance of cancer cells is considered to be closely involved in cancer progression. Programmed death-1 (PD-1) is an inhibitory receptor expressed on activating T cells, and several types of cancer cells were found to express PD-1 ligand 1 (PD-L1) and ligand 2 (PD-L2).<bold>Methods: </bold>In the present study, we investigated PD-L1/2 expression in papillary renal cell carcinoma (pRCC).<bold>Result: </bold>We found PD-L1 expression in 29 of 102 cases, but no PD-L2 expression was seen. PD-L1 expression was not significantly correlated with any clinicopathological factor, including progression-free survival and overall survival. The frequency of PD-L1-positive cases was higher in type 2 (36%) than in type 1 (22%) pRCC; however, there was no significant difference in the percentages of score 0 cases (p value = 0.084 in Chi-square test). The frequency of high PD-L1 expression cases was higher in type 2 (23%) than in type 1 (11%), and the frequency of high PD-L1 expression cases was higher in grade 3/4 (21%) than in grade 1/2 (13%). However, no significant association was found between PD-L1 expression and all clinicopathological factors in pRCC.<bold>Conclusion: </bold>High expression of PD-L1 in cancer cells was potentially associated to highly histological grade of malignancy in pRCC. The evaluation of the PD-L1 protein might still be useful for predicting the efficacy of anti-cancer immunotherapy using immuno-checkpoint inhibitors, however, not be useful for predicting the clinical prognosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712490
Volume :
17
Database :
Complementary Index
Journal :
BMC Urology
Publication Type :
Academic Journal
Accession number :
120800179
Full Text :
https://doi.org/10.1186/s12894-016-0195-x