Back to Search
Start Over
The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.
- Source :
- Scientific Reports; 1/27/2017, p41215, 1p
- Publication Year :
- 2017
-
Abstract
- Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E<subscript>2</subscript> (PGE<subscript>2</subscript>) levels in cells damaged by H<subscript>2</subscript>O<subscript>2</subscript> and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm<superscript>TM</superscript>) indicating a potential cosmeceutical activity of this microalgal species. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 120996307
- Full Text :
- https://doi.org/10.1038/srep41215