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The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.

Authors :
Sansone, Clementina
Galasso, Christian
Orefice, Ida
Nuzzo, Genoveffa
Luongo, Elvira
Cutignano, Adele
Romano, Giovanna
Brunet, Christophe
Fontana, Angelo
Esposito, Francesco
Ianora, Adrianna
Source :
Scientific Reports; 1/27/2017, p41215, 1p
Publication Year :
2017

Abstract

Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E<subscript>2</subscript> (PGE<subscript>2</subscript>) levels in cells damaged by H<subscript>2</subscript>O<subscript>2</subscript> and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm<superscript>TM</superscript>) indicating a potential cosmeceutical activity of this microalgal species. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Database :
Complementary Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
120996307
Full Text :
https://doi.org/10.1038/srep41215