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In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds.
- Source :
- Chemical Communications; 2/4/2017, Vol. 53 Issue 10, p1668-1671, 4p
- Publication Year :
- 2017
-
Abstract
- A new three-component reaction, namely condensation–anti-Michael addition–aromatization, enabling the construction of benzylic compounds is disclosed. This reaction can not only act as an alternative approach to regioselective Csp<superscript>2</superscript>–H trifluoromethylation of arenes through an “aromatic to be” strategy, but also provides a simple, convenient, step-economic, and practical strategy for the in situ generation of electrophilic p-(trifluoromethyl)benzyl species under extremely mild conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- BENZYL compounds
AROMATIC compounds
ELECTROPHILES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 121046741
- Full Text :
- https://doi.org/10.1039/c6cc09268c