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Investigation of Binding Behavior between Drug Molecule 5-Fluoracil and M4L4-Type Tetrahedral Cages: Selectivity, Capture, and Release.
- Source :
- Chemistry - A European Journal; 3/13/2017, Vol. 23 Issue 15, p3542-3547, 6p
- Publication Year :
- 2017
-
Abstract
- Two analogous M<subscript>4</subscript>L<subscript>4</subscript>-type tetrahedral cages (smaller: MOC-19; larger: MOC-22) were synthesized and investigated for their interactions with the anticancer drug 5-fluoracil (5-FU) by NMR spectroscopy, high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), and molecular simulation. The cage's size and window are of importance for the host-guest binding, and consequently the smaller MOC-19 with a more suitable size of cavity window was found to have much stronger hydrogen-bond interactions with 5-FU. The porous nanoparticles of MOC-19 exhibited outstanding behavior for the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 23
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 121807902
- Full Text :
- https://doi.org/10.1002/chem.201606060