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FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.
- Source :
- Diabetic Medicine; Apr2017, Vol. 34 Issue 4, p586-589, 4p
- Publication Year :
- 2017
-
Abstract
- Aim To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. Methods We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. Results The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075]. Conclusions The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 34
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 121850616
- Full Text :
- https://doi.org/10.1111/dme.13288