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Transmission of Hepatitis A Virus through Combined Liver-Small Intestine-Pancreas Transplantation.
- Source :
- Emerging Infectious Diseases; Apr2017, Vol. 23 Issue 4, p590-596, 7p, 2 Diagrams, 2 Charts
- Publication Year :
- 2017
-
Abstract
- Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source. Identical HAV RNA sequences were detected from the serum of both nurses and the organ donor, as well as from the multi-visceral organ recipient's serum and feces; this recipient's posttransplant liver and intestine biopsy specimens also had detectable virus. The other organ recipients tested negative for HAV RNA. Vaccination of the donor might have prevented infection in the recipient and subsequent transmission to the healthcare workers. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATITIS A transmission
TRANSPLANTATION of organs, tissues, etc.
BLOOD transfusion reaction
NURSES
VACCINATION
DISEASES
INFECTIOUS disease transmission
COMPARATIVE studies
HEPATITIS A
HEPATITIS viruses
RESEARCH methodology
MEDICAL cooperation
PATIENT-professional relations
RESEARCH
EVALUATION research
PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 23
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 121976078
- Full Text :
- https://doi.org/10.3201/eid2304.161532