Ten simple rules for responsible big data research.

The article discusses the results of a two-year project which aimed to provide guidance to the National Science Foundation (NSF) on how to best encourage ethical practices in scientific and engineering research involving the use of big data research methods and infrastructures. The assumption that most data represent or impact people should be used to guide one's analysis. Researchers are also encouraged to situate and contextualize data to anticipate privacy breaches and minimize harm.