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Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages.
- Source :
- Science Translational Medicine; 4/27/2016, Vol. 8 Issue 336, p1-13, 13p, 1 Color Photograph, 1 Diagram, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- The article presents a medical study about the initiation of immune tolerance. The said study designed immunogens that avidly bind the UA of the 2F5 broadly reactive neutralizing antibodies (bnAbs) to immunize 2F5 knock-in mice and rhesus macaques. The study found that B cell development is limited by immune tolerance deletion and energy.
Details
- Language :
- English
- ISSN :
- 19466234
- Volume :
- 8
- Issue :
- 336
- Database :
- Complementary Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 122225558
- Full Text :
- https://doi.org/10.1126/scitranslmed.aaf0618