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Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis.

Authors :
Chang, Julia Yu‐Fong
Chiang, Chun‐Pin
Wang, Yi‐Ping
Wu, Yang‐Che
Chen, Hsin‐Ming
Sun, Andy
Source :
Journal of Oral Pathology & Medicine; Apr2017, Vol. 46 Issue 4, p307-312, 6p, 5 Charts
Publication Year :
2017

Abstract

<bold>Background: </bold>Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV).<bold>Methods: </bold>Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG- ) patients, and 100 healthy control subjects.<bold>Results: </bold>The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG- patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG- patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG- patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively.<bold>Conclusion: </bold>We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG- patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09042512
Volume :
46
Issue :
4
Database :
Complementary Index
Journal :
Journal of Oral Pathology & Medicine
Publication Type :
Academic Journal
Accession number :
122273070
Full Text :
https://doi.org/10.1111/jop.12490