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BST-2 restricts IAV release and is countered by the viral M2 protein.
- Source :
- Biochemical Journal; 3/1/2017, Vol. 474 Issue 5, p715-730, 16p
- Publication Year :
- 2017
-
Abstract
- BST-2 (tetherin, CD317, and HM1.24) is induced by interferon and restricts virus release by tethering the enveloped viruses to the cell surface. The effect of BST-2 on influenza A virus (IAV) infection has been inconclusive. In the present study, we report that BST-2 diminishes the production of IAV virus-like particles (VLPs) that are generated by viral neuraminidase and hemagglutinin proteins to a much greater degree than it inhibits the production of wild-type IAV particles. This relatively weaker inhibition of IAV is associated with reduction in BST-2 levels, which is caused by the M2 protein that interacts with BST-2 and leads to down-regulation of cell surface BST-2 via the proteasomal pathway. Similarly to the viral antagonist Vpu, M2 also rescues the production of human immunodeficiency virus-1 VLPs and IAV VLPs in the presence of BST-2. Replication of wild-type and the M2-deleted viruses were both inhibited by BST-2, with the M2-deleted IAV being more restricted. These data reveal one mechanism that IAV employs to counter restriction by BST-2. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02646021
- Volume :
- 474
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Biochemical Journal
- Publication Type :
- Academic Journal
- Accession number :
- 122445581
- Full Text :
- https://doi.org/10.1042/BCJ20160861