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Changes in bone turnover markers with HIV seroconversion and ART initiation.
- Source :
- Journal of Antimicrobial Chemotherapy (JAC); May2017, Vol. 72 Issue 5, p1456-1461, 6p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Osteoporosis is common among HIV-infected persons and contributes to risk of fragility fracture. While ART initiation is associated with decreases in bone mineral density and increases in bone turnover, the impact of HIV on bone metabolism is unclear.<bold>Methods: </bold>We identified men at the Chicago site of the Multicenter AIDS Cohort Study who HIV seroconverted while under observation. Concentrations of 25-OH vitamin D, bone turnover markers [procollagen type 1 N terminal propeptide (P1NP), osteocalcin (OC), C-telopeptide (CTX)] and sclerostin were measured from stored serum obtained at pre-HIV infection, pre-ART and post-ART initiation timepoints. Mixed models, with each biomarker as an outcome, were fitted. Timepoint, age, CD4 count (cells/mm 3 ), HIV-viral suppression, season and an age by timepoint interaction term were considered as fixed effects.<bold>Results: </bold>Data from 52 participants revealed that median duration between HIV seroconversion and ART initiation was 8.7 years (IQR 3.7-11.6). Median CD4 and plasma HIV-RNA concentrations were 445 (IQR 298.5-689) and 20 184 copies/mL (IQR 6237-64 340), respectively, at the pre-ART timepoint. Multivariate analyses demonstrated pre-HIV infection levels of OC that were higher than pre-ART levels (6.8 versus 5.7 ng/mL, P = 0.04); and pre-ART levels of sclerostin that were higher than post-ART levels (0.033 versus 0.02 ng/mL, P <0.001). No changes in P1NP, CTX and 25-OH vitamin D levels were detected.<bold>Conclusions: </bold>HIV seroconversion was associated with decreased OC levels while ART initiation was associated with decreases in sclerostin, a negative regulator of bone formation. Our results suggest that both HIV infection and ART have an impact on bone metabolism in white men. [ABSTRACT FROM AUTHOR]
- Subjects :
- OSTEOPOROSIS
HIV-positive persons
BONE density
SCLEROSTIN
OSTEOCALCIN
THERAPEUTICS
BONE physiology
BONE remodeling
BONE morphogenetic proteins
BONES
COLLAGEN
COMPARATIVE studies
HIV infections
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
PEPTIDES
RESEARCH
RESEARCH funding
GENETIC markers
EVALUATION research
HIGHLY active antiretroviral therapy
CD4 lymphocyte count
Subjects
Details
- Language :
- English
- ISSN :
- 03057453
- Volume :
- 72
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Academic Journal
- Accession number :
- 122690350
- Full Text :
- https://doi.org/10.1093/jac/dkx011