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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
- Source :
- Science Translational Medicine; 3/15/2017, Vol. 9 Issue 381, p1-10, 10p
- Publication Year :
- 2017
-
Abstract
- The article reports on the mimicry of an HIV infection in neutralizing antibody (bnAbs) epitope with a synthetic glycopeptide. It cites on the goal of the HIV vaccine in overcoming virus variability in inducing bnAbs. The article also reports on the study of ontogeny of the V3-glycan bnAb DH270 lineage in which an unmutated common ancestor (UCA) antibody for the DH270 lineage did not bind HIV-1 Env glycoprotein.
- Subjects :
- HIV infections
AIDS vaccines
IMMUNOGLOBULINS
GLYCANS
ONTOGENY
GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 19466234
- Volume :
- 9
- Issue :
- 381
- Database :
- Complementary Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 122734341
- Full Text :
- https://doi.org/10.1126/scitranslmed.aai7521