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Decreased flow-mediated dilatation in patients with rheumatoid arthritis: a meta-analysis.
- Source :
- Postgraduate Medical Journal; May2017, Vol. 93 Issue 1099, p260-265, 6p, 1 Diagram, 4 Charts, 2 Graphs
- Publication Year :
- 2017
-
Abstract
- <bold>Objectives: </bold>To derive a more precise comparison of flow-mediated dilatation (FMD%) of the brachial artery between patients with rheumatoid arthritis (RA) and normal controls by performing a meta-analysis of appropriate studies.<bold>Methods: </bold>PubMed and EMBASE databases were searched for all relevant articles. STATA (V.12.0) software was used to perform the meta-analysis. Quality estimation of all appropriate studies was evaluated according to the Newcastle-Ottawa Scale (NOS). Standardised mean difference (SMD) with 95% CIs were calculated with a random-effects model. The Cochrane Q test and I2 statistic were used to evaluate the heterogeneity. Funnel plot and Egger's test were conducted to assess the publication bias.<bold>Results: </bold>In total, 464 articles were obtained after searching the two databases. Ten studies were included in the meta-analysis on the basis of the inclusion and exclusion criteria. Significant heterogeneity was observed among these 10 studies (Q=102.89, p<0.001, I2=91.3%) with random-effects modelling. The results showed that the RA group had significantly lower FMD% (SMD: -1.405; 95% CI -1.992 to -0.817; p<0.001) than the control group. Egger's test (p=0.004) indicated that the funnel plot showed a skewed or asymmetrical shape and publication bias existed. Sensitivity analyses suggested the robustness and credibility of our results.<bold>Conclusions: </bold>FMD% in patients with RA is significantly decreased compared with healthy controls. FMD% is an important early marker of atherosclerosis. It may be used as a parameter to forecast cardiovascular disease in patients with RA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00325473
- Volume :
- 93
- Issue :
- 1099
- Database :
- Complementary Index
- Journal :
- Postgraduate Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- 122738419
- Full Text :
- https://doi.org/10.1136/postgradmedj-2016-134068