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Safety and efficacy of therapeutic membrane plasmapheresis in the treatment of Guillain-Barré syndrome: A study from a tertiary care hospital from India.
- Source :
- Neurology India; May/Jun2017, Vol. 65 Issue 3, p527-531, 5p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Reports on therapeutic plasma exchange (TPE) with the standard hemodialysis equipment are scarce, particularly from developing countries.<bold>Materials and Methods: </bold>A retrospective analysis of safety and efficacy of membrane-based TPE with a standard hemodialysis equipment for the treatment of severe Guillain-Barré syndrome (GBS) was conducted.<bold>Results: </bold>A total of 120 TPE sessions were performed in 31 GBS patients over a period of 5½ years. Each patient underwent a mean of 3.8 ± 1.5 TPE sessions. One (3.2%) patient died. Thirty (96.8%) patients survived and recovered. At 2 weeks, there was a significant improvement in the grade of power in both the upper and lower extremities (P = 0.001) and a significant decrease in the GBS disability grade (P = 0.001). Twenty four (77.4%) patients were able to walk unaided. Complications observed were: hypotension in 12 (10%), accelerated hypertension in 3 (2.5%), chills and rigors in 5 (4.2%), bleeding in 5 (4.2%), and filter clotting in 6 (5%) sessions. One patient experienced an anaphylactoid reaction and 1 patient survived a cardiorespiratory arrest. Two patients developed aspiration pneumonia and 1 patient developed catheter site infection.<bold>Conclusions: </bold>Membrane-based TPE can be conveniently delivered with the standard hemodialysis equipment. It is a safe, effective, and comparatively less expensive treatment option for GBS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00283886
- Volume :
- 65
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Neurology India
- Publication Type :
- Academic Journal
- Accession number :
- 122980834
- Full Text :
- https://doi.org/10.4103/neuroindia.NI_907_15