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Anti-inflammatory Role of Pilose Antler Peptide in LPS-Induced Lung Injury.
- Source :
- Inflammation; Jun2017, Vol. 40 Issue 3, p904-912, 9p
- Publication Year :
- 2017
-
Abstract
- The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry weight (W/D) ratio and lung myeloperoxidase (MPO) activity and restored LPS-induced lung histopathological changes. PAP also increased super oxide dismutase (SOD) level and inhibited malondialdehyde (MDA) content and levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) in LPS-stimulated mice. Furthermore, we demonstrated that PAP inhibited Rho/NF-κB pathway in LPS-induced mice. Our experimental results indicated that the protective mechanism of PAP might be attributed partly to the inhibition of Rho/NF-κB pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNGS
WOUNDS & injuries
MICE
MALONDIALDEHYDE
MURIDAE
Subjects
Details
- Language :
- English
- ISSN :
- 03603997
- Volume :
- 40
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 123023710
- Full Text :
- https://doi.org/10.1007/s10753-017-0535-3