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Role of 4-1BB:4-1BB ligand in cancer immunotherapy.
- Source :
- Cancer Gene Therapy; Mar2004, Vol. 11 Issue 3, p215-226, 12p
- Publication Year :
- 2004
-
Abstract
- The activation of T cells plays a central role in antitumor immunity. In order to activate naïve T cells, two key signals are required. Signal one is provided through the T-cell receptor (TCR) while signal two is that of costimulation. The CD28:B7 molecules are one of the best-studied costimulatory pathways, thought to be the main mechanism through which primary T-cell stimulation occurs. However, a number of molecules have been identified which serve to amplify and diversify the T-cell response, following initial T-cell activation. These include the more recently described 4-1BB:4-1BB ligand (4-1BBL) molecules. 4-1BB:4-1BBL are a member of the TNFR:TNF ligand family, which are expressed on T cells and antigen-presenting cells (APCs), respectively. Therapies utilizing the 4-1BB:4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. In this paper, we focus on the 4-1BB:4-1BBL costimulatory molecules. In particular, we will describe the structure and function of the 4-1BB molecule, its receptor and how 4-1BB:4-1BBL costimulation has and may be used for the immunotherapy of cancer.Cancer Gene Therapy (2004) 11, 215-226. doi:10.1038/sj.cgt.7700670 Published online 12 December 2003 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09291903
- Volume :
- 11
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cancer Gene Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 12324703
- Full Text :
- https://doi.org/10.1038/sj.cgt.7700670