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Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men.
- Source :
- Journal of Infectious Diseases; May2017, Vol. 215 Issue 9, p1352-1361, 10p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection.<bold>Methods: </bold>We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years.<bold>Results: </bold>Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: from 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque.<bold>Conclusions: </bold>sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons. [ABSTRACT FROM AUTHOR]
- Subjects :
- MACROPHAGES
INFLAMMATION
CAROTID artery
ATHEROSCLEROSIS
HIV
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 215
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 123435894
- Full Text :
- https://doi.org/10.1093/infdis/jix082