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Development of a kit-like radiofluorinated biomolecule leading to a controlled self-assembly of 18F nanoparticles for a smart PET imaging application.
- Source :
- Chemical Communications; 6/18/2017, Vol. 53 Issue 48, p6476-6479, 4p
- Publication Year :
- 2017
-
Abstract
- A kit-like <superscript>18</superscript>F-fluorination method has been successfully applied to prepare an activatable probe 1 with good radiochemical yield and high specific activity. The probe has good in vitro stability and favorable cell membrane permeability. A controlled condensation reaction was initiated, and self-assembly into nanoparticles occurred when the probe was in a reducing environment. Positron emission tomography (PET) imaging of the biothiol level in living subjects was conveniently and precisely realized using this probe. The present study may provide a new platform for the development of “smart” PET tracers for tumor imaging. [ABSTRACT FROM AUTHOR]
- Subjects :
- MOLECULAR self-assembly
NANOPARTICLES
POSITRON emission tomography
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 48
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 123555724
- Full Text :
- https://doi.org/10.1039/c7cc03040a