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Decreased frequency of peripheral blood CD8+CD25+FoxP3+regulatory T cells correlates with IL-33 levels in pre-eclampsia.
- Source :
- Hypertension in Pregnancy; May2017, Vol. 36 Issue 2, p217-225, 9p, 1 Chart, 4 Graphs
- Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>We aimed to investigate the role of CD8+CD25+Foxp3+regulatory T (Treg) cells in pre-eclampsia (PE).<bold>Methods: </bold>This was a cross-sectional study of 46 patients with PE and 24 normotensive women within the third trimester of gestation. We analyzed the percentages of CD8+CD25+Foxp3+Treg cells in peripheral blood using flow cytometry and the serum levels of interleukin (IL)-6, IL-17A, IL-10, TGF-β1, IL-1β, and IL-33 by Luminex 200.<bold>Results: </bold>We found that patients with PE had lower percentages of CD8+CD25+Foxp3+Treg cells than normotensive pregnant women. In addition, the percentage of CD8+CD25+Foxp3+Treg cells was positively correlated with IL-33 concentration and negatively correlated with IL-17A concentration in patients with PE. We also found that IL-33 treatment can induce proliferation of CD8+CD25+Foxp3+Treg cells in vitro.<bold>Conclusions: </bold>These findings suggest that the reduced CD8+CD25+Foxp3+Treg cells may play a role in the pathogenesis of PE. Abbreviations PE: pre-eclampsia; PBMCs: peripheral blood mononuclear cells; CTLA-4: cytotoxic T-lymphocyteantigen-4; APCs: antigen presenting cells; TGF-β: transforming growth factor-β; IL: interleukin; Treg: cells regulatory T cells; PBS: phosphate-buffered saline; Foxp3: forkhead Box protein 3; HELLPs: hemolysis, elevated liver enzyme and low platelet syndrome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 36
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 123568002
- Full Text :
- https://doi.org/10.1080/10641955.2017.1302470