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Primary Polyomavirus Infection, Not Reactivation, as the Cause of Trichodysplasia Spinulosa in Immunocompromised Patients.
- Source :
- Journal of Infectious Diseases; 4/1/2017, Vol. 215 Issue 7, p1080-1084, 5p
- Publication Year :
- 2017
-
Abstract
- Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from latency. For the rare skin disease trichodysplasia spinulosa, we show that manifestations of the causative polyomavirus (TSPyV) occur during primary infection of the immunosuppressed host. High TSPyV loads in blood and cerebrospinal fluid, sometimes coinciding with cerebral lesions and neuroendocrine symptoms, marked the acute phase of trichodysplasia spinulosa, whereas initiation and maturation of TSPyV seroresponses occurred in the convalescent phase. TSPyV genomes lacked the rearrangements typical for reactivating polyomaviruses. These findings demonstrate the clinical importance of primary infection with this rapidly expanding group of human viruses and explain the rarity of some novel polyomavirus-associated diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- POLYOMAVIRUS diseases
SPINULOSIDA
IMMUNOCOMPROMISED patients
VIRAL load
INFECTION
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 215
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 123570625
- Full Text :
- https://doi.org/10.1093/infdis/jiw403