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Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.
- Source :
- International Immunology; Apr2017, Vol. 29 Issue 4, p149-155, 7p
- Publication Year :
- 2017
-
Abstract
- Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system. [ABSTRACT FROM AUTHOR]
- Subjects :
- MESSENGER RNA
ZINC-finger proteins
IMMUNE system
TRISTETRAPROLIN
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 09538178
- Volume :
- 29
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- International Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 123595294
- Full Text :
- https://doi.org/10.1093/intimm/dxx015