CuI Supported on Protonated Trititanate Nanotubes: A Reusable Catalyst for the One-Pot Synthesis of Propargylamines via A3-Coupling.

CuI catalysts supported on protonated trititanate nanotubes (CuI/HTNT) were prepared and used as catalysts for the synthesis of propargylamines via A³ (aldehyde, amine and acetylene) coupling under solvent-free conditions. The results revealed that the CuI/HTNT with 5 wt % CuI had the best catalytic activity. The protocol provides access to a wide range of propargylamines in excellent yields (up to 98 %). The prepared catalysts were characterized by TEM, XRD, N₂-adsorption desorption, EDS and ICP-MS analysis. The catalyst can be recovered by centrifugation and reused in further catalytic reactions, its activity remaining largely unchanged for five successive runs. [ABSTRACT FROM AUTHOR]